Venixxa. To relieve painful, heavy or swollen legs

The #1 doctor recommended over-the-counter brand to treat mild-to-moderate chronic venous disease. 1

How does Venixxa work?

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Venoactive treatments, like Venixxa, are designed to help relieve the symptoms of chronic venous disease by strengthening the tone of your veins, which continue to weaken as chronic venous disease progresses*.

Venixxa has a dual mechanism of action; its anti-inflammatory venoprotective action protects the capillaries or tiny blood vessels which improves microcirculation, and venous tone, in order to help relieve chronic venous disease symptoms such as heavy, painful and swollen legs. 8

*For information only. Venixxa does not treat all stages of chronic venous disease

Tackle leg pain from the inside

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Venixxa is a clinically proven, effective and convenient oral treatment synthetically made from a natural-origin material, extracted from immature oranges, and specially formulated for maximum absorption. 2

This improved absorption means Venixxa can effectively treat veins from the inside and provide relief from painful and heavy leg symptoms of chronic venous disease. 2

Demonstrated Effect of Venixxa Over 8 Weeks

4 weeks 4

8 weeks 4

Leg pain



Sensation of heaviness



Sensation of swelling



Relieves Symptoms

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The #1 doctor recommended over-the-counter brand to treat mild-to-moderate chronic venous disease. 1

Clinical Studies have shown that Venixxa can relieve leg pain and the sensations of heaviness and swelling by up to 50% after only one month of use. These figures were even higher after two months of treatment.

To benefit from your Venixxa treatment, you should take your medication as recommended. Be sure to monitor your condition closely and speak with a healthcare practitioner if you have any concerns.

Naturally sourced, scientifically prepared.

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The active ingredient in Venixxa is a micronized purified flavonoid fraction (MPFF) containing 90% diosmin and 10% other flavonoids expressed as hesperidin.

Manufacturing secrets 5,6,7

  1. The manufacturing of Venixxa begins by harvesting small, immature oranges from all over the world. These are harvested, dried for 15 days in the sun, and then crushed to extract a natural substance which is used to produce the medicine: hesperidin.
  2. Once extracted, hesperidin is transformed by an industrial process into an active substance: the flavonoid fraction. This secret industrial process gives this flavonoid fraction a composition of: 90% diosmin and 10% carefully dosed flavonoids.
  3. The flavonoid fraction is then purified and dried to remove all impurities. The objective of this step is to obtain a quality flavonoid fraction.
  4. The purified flavonoid fraction is very poorly absorbed by the intestine because the flavonoid particles are very large. The micronization process therefore consists of reducing the size of the flavonoid particles by making them collide with each other. The purified micronized flavonoid fraction is then better absorbed in the body.
  5. The micronized purified flavonoid fraction is then transformed into Venixxa tablets using a compression step.
  6. The tablets are then put in a blister (tablet blister) and inserted into the Venixxa boxes. These boxes will then reach pharmacies

Safety Information:

Venixxa 500mg Safety Information

This product may not be suitable for you. Always read and follow the label and package insert carefully. Do not use Venixxa if you are pregnant or breastfeeding. If you are taking prescription medication, consult a healthcare practitioner prior to use. Consult a healthcare practitioner if chronic venous disease symptoms persist or worsen. If you suffer or experience inflammation of the skin, thrombophlebitis or subcutaneous induration, severe pain, ulcers, sudden swelling of one or both legs, cardiac or renal insufficiency or disorder, consult a healthcare practitioner.

Adverse Reactions 

Hypersensitivity/allergy, gastrointestinal discomfort, dizziness, headaches, malaise and skin reactions have been known to occur; in which case, discontinue use and consult a health care practitioner.


  1. Based on iQvia data, 2023.
  2. Adapté de Nicolaides A, Kakkos S, Baekgaard N, et al. Management of chronic venous disorders of the lower limbs. Guidelines according to scientific evidence. Part I. Int Angiol. 2018;37(3):181-254.1
  3. Garner RC, Garner JV, Gregory S, Whattam M, Calam A, Leong D. Comparison of the absorption of micronized (Daflon 500 mg) and nonmicronized 14C-diosmin tablets after oral administration to healthy volunteers by accelerator mass spectrometry and liquid scintillation counting. J Pharm Sci. 2002;91:32-40
  4. Gilly R, Pillion G, Frileux C. Evaluation of a new venoactive micronized flavonoid fraction (S 5682) in symptomatic disturbances of the venolymphatic circulation of the lower limb: a double-blind, placebo-controlled study. Phlebology. 1994;9:67-70.
  5. Maggioli. Phlebolymphology. 2016; 23(2):82-91.​
  6. Johnston et al. Phlebology. 1994;9(Suppl.1):4-6.
  7. Paysant et al. International Angiology. 2007;27(1):81-85.6.
  8. Katherine A. Lyseng-Williamson and Caroline M. Perry. Micronised Purified Flavonoid Fraction A Review of its Use in Chronic Venous Insufficiency, Venous Ulcers and Haemorrhoids 

*For information only. Venixxa does not treat all stages of chronic venous disease.